IMGT GeneView

IMGT GeneView provides integrated sequence, map and polymorphism views of genes for immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and other immune system proteins for immunogenetics analysis.

Key Features:

• Integration with IMGT/LocusView: Integrated within the IMGT/LocusView framework to present comprehensive gene locus representations for immune system proteins.
• IMGT-ONTOLOGY Foundation: Implements IMGT-ONTOLOGY concepts including standardized keywords, labels, nomenclature, unique numbering systems and the IMGT Colliers de Perles (numerotation) concept.
• Access to Diverse Data Types: Provides nucleotide and protein sequences, gene maps, genetic polymorphisms and specificity annotations.
• Genome Analysis Support: Supports exploration and analysis of genomic data related to immune system proteins and complements IMGT/GeneSearch.

Scientific Applications:

• Medical Research: Enables repertoire and mutation analyses relevant to autoimmune diseases, AIDS, leukemias, lymphomas and myelomas, including clinical mutation analysis in leukemia and lymphoma.
• Veterinary Research: Facilitates study of IG and TR repertoires across farm and wildlife species for veterinary immunogenetics.
• Genome Diversity and Evolution Studies: Supports analyses of genome diversity and evolution in adaptive immune responses.
• Biotechnology and Therapeutics: Supports antibody engineering and therapeutic development including single-chain fragment variable (scFv), phage display, combinatorial libraries, humanized antibodies, grafting and immunotherapy applications.

Methodology:

Operates within the IMGT framework using standardized data formats and IMGT-ONTOLOGY for interoperability and integrates data from IMGT databases including IMGT/LIGM-DB and IMGT/MHC-DB.