IMGT LIGM-DB

IMGT LIGM-DB provides a curated repository of published immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences with IMGT-ONTOLOGY-aligned annotations to support immunogenetics, repertoire analysis, and antibody engineering.

Key Features:

• Comprehensive Sequence Collection: Includes all published IG and TR nucleotide sequences sourced from generalist databases, covering genomic and expressed sequences.
• Detailed Annotation: Provides sequence identification, gene and allele classification, motif descriptions, codon and amino acid numbering, and sequence acquisition details aligned with IMGT-ONTOLOGY concepts.
• Sequence Translations and Analyses: Supplies IMGT flat files, translations of coding regions, and analyses via IMGT/V-QUEST.
• Support for High-Throughput Data: Incorporates next-generation sequencing (NGS) high-throughput IG and TR repertoire data for repertoire analyses.
• Integration with IMGT Resources: Annotations serve as a primary source for IMGT/GENE-DB and the IMGT reference directory and support gene, sequence, and 3D structure analyses.

Scientific Applications:

• Basic Immunology: Enables comparative and structural studies of IG and TR sequences to inform immune system function.
• Veterinary Science: Facilitates analysis of IG and TR repertoires in non-human species for veterinary research.
• Medical Research: Supports studies of antibody and T cell receptor diversity and specificity in human disease contexts.
• Clinical Mutation Analysis: Supports mutation analysis in leukemia and lymphoma to aid clinical diagnostics and treatment strategies.
• Antibody Engineering: Provides standardized sequence and numbering information for antibody design and engineering.
• Adaptive Immune Repertoire Analysis: Enables genomic and expressed IG and TR repertoire analyses, including NGS high-throughput data, to study adaptive immune responses.

Methodology:

Built on IMGT-ONTOLOGY axioms using standardized keywords, labels, nomenclature, unique numbering systems and the IMGT Colliers de Perles (numerotation) method for gene, sequence and 3D structure analysis.