IMGT LocusView

IMGT LocusView provides an integrated, standardized representation of immunoglobulin (IG), T cell receptor (TR), and major histocompatibility complex (MH) loci to support immunogenetics analyses.

Key Features:

• Standardized Data Access: Provides standardized nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, and 2D and 3D structures for IG, TR, and MH loci.
• Integrated Databases: Integrates data from IMGT resources including IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB, IMGT/GENE-DB, and IMGT/3Dstructure-DB.
• Sequence, Genome and 3D-Structure Analysis Tools: Supports analysis with IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/GeneSearch, IMGT/GeneView, and IMGT/StructuralQuery.
• Web Services and Interoperability: Employs IMGT-Choreography and IMGT-ML (XML Schema) to enable dynamic interactions between IMGT web services and processing of complex biological and clinical requests.

Scientific Applications:

• Medical Research: Enables analysis of IG and TR repertoires, IG antibody sites and TR recognition sites in studies of autoimmune diseases, AIDS, leukemias, lymphomas, and myelomas.
• Veterinary Research: Supports analysis of IG and TR repertoires across farm and wild life species for comparative and veterinary immunogenetics.
• Genome Diversity and Evolution Studies: Facilitates investigation of genome diversity and the evolution of adaptive immune responses across vertebrates.
• Biotechnology and Therapeutics: Informs antibody engineering and therapeutic development including single chain Fragment variable (scFv), phage display, combinatorial libraries, chimeric, humanized, and human antibodies, as well as diagnostics, grafts, immunotherapy, and vaccinology.

Methodology:

IMGT-ONTOLOGY provides the semantic framework for data consistency and accuracy; IMGT-Choreography, web services, and the IMGT-ML XML Schema enable automated queries, interoperability, and processing of complex biological and clinical requests.