IMGT StatClonotype

IMGT StatClonotype performs statistical analysis of IMGT/HighV-QUEST output to detect significant changes in immunoglobulin (IG) and T cell receptor (TR) clonotype diversity and expression at the amino acid level.

Key Features:

• Statistical procedure: Employs a generic statistical procedure tailored to identify significant changes in IG and TR clonotype diversity and expression at the amino acid level.
• IMGT gene and allele nomenclature: Uses IMGT standardized nomenclature to identify variable (V), diversity (D), and joining (J) genes and alleles.
• IMGT-ONTOLOGY concepts: Applies IMGT-ONTOLOGY concepts of identification, description, classification, and numerotation in data analysis.
• High-throughput processing: Supports comparative statistical analyses on batches of up to one million nucleotide sequences.
• Input compatibility: Processes output generated by IMGT/HighV-QUEST.

Scientific Applications:

• Vaccination: Analyzes changes in IG and TR clonotypes to evaluate immune responses associated with vaccination.
• Cancer research: Assesses immune receptor diversity to study tumor-associated immune repertoire changes.
• Infectious diseases: Profiles host immune receptor responses to infections by characterizing IG and TR clonotype dynamics.
• Autoimmunity and lymphoproliferative disorders: Identifies clonal expansions relevant to autoimmune conditions and lymphoid malignancies.

Methodology:

Processes IMGT/HighV-QUEST output using a generic statistical procedure to detect significant changes in IG and TR clonotype diversity and expression at the amino acid level, employing IMGT gene/allele nomenclature and IMGT-ONTOLOGY concepts and supporting batch processing of up to one million nucleotide sequences.