IMGT StructuralQuery

IMGT StructuralQuery retrieves and analyzes 3D structures of immunological proteins to identify gene/allele assignments, delimit variable (V), constant (C) and groove (G) domains, and map amino acid positions using the IMGT unique numbering system.

Key Features:

• 3D Structure Database Access: Interfaces with IMGT/3Dstructure-DB to retrieve known immunological protein 3D structures.
• Structural Criteria Search: Retrieves IMGT/3Dstructure-DB entries using criteria related to variable (V), constant (C), or groove (G) domains for structural analysis and comparisons.
• Ontology-Based Annotation: Applies IMGT-ONTOLOGY for standardized classification, keywords, labels, nomenclature, and IMGT unique numbering.
• Graphical Representations and Contact Analysis: Generates 2D Collier de Perles representations and contact analysis results to visualize structural interactions.

Scientific Applications:

• Medical Research: Analysis of immune protein structures in autoimmune diseases, AIDS, leukemias, lymphomas, and myelomas.
• Veterinary Research: Studies of genome diversity and evolution in vertebrates.
• Biotechnology and Therapeutics: Supports antibody engineering, phage displays, combinatorial libraries, grafts, and immunotherapy development.
• Clinical Applications: Mutation analysis for leukemia and lymphoma diagnostics and treatment strategies.

Methodology:

Retrieves entries from IMGT/3Dstructure-DB using structural criteria; applies IMGT-ONTOLOGY and IMGT Scientific chart rules for classification, nomenclature and IMGT unique numbering; performs gene/allele identification, domain delimitation and amino-acid position mapping; generates Collier de Perles 2D representations and contact analysis results.