MyGeneset.info

MyGeneset.info provides programmatic access to integrated gene-set definitions, identifiers, and annotations to support pathway, disease, and comparative genomics analyses.

Key Features:

• Integrated annotations: Provides an API that returns comprehensive annotations for gene sets by leveraging MyGene.info for gene-centric annotations.
• Multi-resource imports: Imports gene sets from Wikipathways, Comparative Toxicogenomics Database (CTD), Reactome, Small Molecule Pathway Database (SMPDB), Molecular Signatures Database (MSigDB), Gene Ontology (GO), and Disease Ontology (DO).
• Extensive coverage: Offers read-only access to approximately 180,000 gene sets encompassing humans, mice, yeast, and the black cottonwood tree.
• User-created gene sets: Supports creation and management of user-defined gene sets accessible via the same API.
• FAIR compliance: Enables gene sets to be findable, accessible, interoperable, and reusable.

Scientific Applications:

• Pathway Analysis: Enables analysis of biological pathways and interactions using pre-defined or custom gene sets.
• Disease Research: Facilitates investigation of disease-associated gene sets to study genetic underpinnings and identify candidate therapeutic targets.
• Comparative Genomics: Supports cross-species comparison of gene sets across humans, model organisms, and other species for evolutionary and functional genomics studies.

Methodology:

Imports gene sets from Wikipathways, CTD, Reactome, SMPDB, MSigDB, GO, and DO; leverages MyGene.info for gene-centric annotations; and exposes a unified API providing read-only access to ~180,000 gene sets and endpoints for user-created gene sets.