progeny

"PROGENy" (Pathway RespOnsive GENes) is a novel computational method designed to accurately infer cell signaling pathway activity from gene expression data, addressing critical limitations in traditional approaches to studying aberrant cell signaling in diseases like cancer. Conventional methods often directly map gene expression to specific pathway components, neglecting the significant role of post-translational modifications and the context-specific nature of downstream signatures.

PROGENy identifies a common core of responsive genes across various conditions by utilizing a vast compendium of publicly available perturbation experiments, offering several key advantages over conventional pathway mapping techniques. First, it can effectively recover the impact of known driver mutations on signaling pathways. Second, PROGENy enhances the identification and characterization of strong markers for drug indications, facilitating targeted drug research. It distinguishes between oncogenic and tumor suppressor pathways concerning patient survival, providing critical insights for therapeutic strategies.