2DImpute

'2DImpute' is an imputation method to correct false zeros (dropouts) in single-cell RNA-sequencing (scRNA-seq) data. It excels by preventing excessive correction, predicting and imputing values for false zeros using the relationships between genes and cells in the expression matrix.

Topic

RNA-Seq;Gene expression;Cell biology;Exome sequencing;Genomics

Detail

  • Operation: Imputation;Standardisation and normalisation

  • Software interface: Library

  • Language: R

  • License: The GNU General Public License v3.0

  • Cost: Free

  • Version name: 0.1.0

  • Credit: -

  • Input: -

  • Output: -

  • Contact: Dimitris Anastassiou d.anastassiou@columbia.edu

  • Collection: -

  • Maturity: -

Publications

  • 2DImpute: imputation in single-cell RNA-seq data from correlations in two dimensions.
  • Zhu K and Anastassiou D. 2DImpute: imputation in single-cell RNA-seq data from correlations in two dimensions. 2DImpute: imputation in single-cell RNA-seq data from correlations in two dimensions. 2020; 36:3588-3589. doi: 10.1093/bioinformatics/btaa148
  • https://doi.org/10.1093/BIOINFORMATICS/BTAA148
  • PMID: 32108864
  • PMC: PMC7267828

Download and documentation

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