ACES

ACES is a software tool that allows researchers to analyze the conservation of specific sequences of interest, such as enhancers, promoters, or exons, across multiple reference genomes. It was developed to address the challenge of querying a specific sequence against an abundance of new reference genomes that become available through large-scale sequencing efforts. The tool uses BLAST to generate hits against each of the reference genomes and produces multiple sequence alignments, graphical fragment assemblies, and phylogenetic trees. These data files can help researchers gain insights into the conservation of their query sequence. ACES is available at and users can contact Tychele@wustl.edu for more information. Supplementary Figure 1 provides additional details about the tool's output.