AIDA

AIDA is a software tool that uses an ab initio domain assembly approach to assemble multi-domain protein structures. It can detect homologous templates for individual domains and predict domain assignments from the provided sequence. The tool has been tested on experimentally solved structures of multi-domain proteins and was able to accurately determine the relative domain positions among the top 5000 models in 86% of cases. AIDA package and benchmark sets used are available for download, and the tool could successfully determine domain boundaries for 97% of targets in a blind test consisting of 95 CASP10 targets.

Topic

Protein folds and structural domains;Structure prediction;Sequence assembly;Small molecules;Protein structural motifs and surfaces

Detail

  • Operation: Protein fold recognition;Ab initio structure prediction;Sequence assembly;Molecular docking;Protein domain recognition

  • Software interface: Web user interface

  • Language: -

  • License: -

  • Cost: Free

  • Version name: -

  • Credit: The National Institute of Health, the National Natural Science Foundation of China.

  • Input: -

  • Output: -

  • Contact: Adam Godzik adam@sanfordburnham.org

  • Collection: -

  • Maturity: -

Publications

  • AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain-domain interaction prediction.
  • Xu D, et al. AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain-domain interaction prediction. AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain-domain interaction prediction. 2015; 31:2098-105. doi: 10.1093/bioinformatics/btv092
  • https://doi.org/10.1093/bioinformatics/btv092
  • PMID: 25701568
  • PMC: PMC4481839

Download and documentation

    Currently not available or not maintained.

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