ASSIGN

The software tool "ASSIGN" is a pathway profiling toolkit that enables robust and context-specific pathway analyses by efficiently capturing pathway activity in heterogeneous sets of samples and across profiling technologies. It is based on a flexible Bayesian factor analysis approach that allows for simultaneous profiling of multiple correlated pathways and adaptation of pathway signatures into specific diseases. The software tool is demonstrated to be versatile in estimating pathway activity in simulated data, cell lines perturbed pathways and in primary tissues samples including The Cancer Genome Atlas breast carcinoma samples and liver samples exposed to genotoxic carcinogens.