BUFET

BUFET (Bitset-based Unbiased Functional Enrichment Analysis Tool) is an innovative computational tool designed to streamline the process of miRNA functional enrichment analysis. This analysis is critical for understanding the biological processes regulated by groups of miRNAs, which target genes involved in these processes. Despite its significance, the traditional approach to miRNA functional enrichment analysis is known for being computationally intensive and time-consuming, presenting a bottleneck for researchers in the field.

The primary advantage of BUFET lies in its ability to significantly reduce the time required for executing unbiased miRNA functional enrichment analyses without compromising the quality of the results. This improvement in efficiency is achieved through two key innovations:
1. Efficient Bitset-Based Methods: BUFET utilizes bitset-based data structures to manage and query data more efficiently. This choice allows for faster computational operations, especially beneficial when dealing with large datasets common in genomic research.
2. Parallel Computation Techniques: By leveraging parallel computation, BUFET distributes the workload across multiple processor cores, significantly speeding up the analysis process. This approach ensures that the tool can take full advantage of modern multi-core processing environments to accelerate computations.

Topic

Bioinformatics

Detail

  • Operation: Gene-set enrichment analysis

  • Software interface: Command-line user interface

  • Language: C++,Python

  • License: The GNU General Public License v3.0

  • Cost: Free with restrictions

  • Version name: -

  • Credit: The European Commission.

  • Input: -

  • Output: Text data [CSV]

  • Contact: Konstantinos Zagganas kzagganas@uop.gr

  • Collection: -

  • Maturity: Stable

Publications

  • BUFET: boosting the unbiased miRNA functional enrichment analysis using bitsets.
  • Zagganas K, et al. BUFET: boosting the unbiased miRNA functional enrichment analysis using bitsets. BUFET: boosting the unbiased miRNA functional enrichment analysis using bitsets. 2017; 18:399. doi: 10.1186/s12859-017-1812-8
  • https://doi.org/10.1186/s12859-017-1812-8
  • PMID: 28874117
  • PMC: PMC5585958

Download and documentation


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