BatchQC

BatchQC is a software pipeline developed to address the technical biases introduced by collecting or processing sequencing and microarray samples in multiple batches or at different times, a common issue in '-omics' research. Unlike existing batch adjustment tools, BatchQC allows for correcting batch effects and provides interactive visualizations and statistics to evaluate the necessity and impact of such adjustments. Users can assess the effectiveness of various correction methods interactively through the pipeline. BatchQC has demonstrated its effectiveness on both simulated and real datasets. The tool enhances the reliability of '-omics' data analysis by ensuring that batch effects are appropriately accounted for.

Topic

Sequencing;Microarray experiment;Data quality management

Detail

  • Operation: Validation;Statistical calculation

  • Software interface: Command-line user interface;Library

  • Language: R

  • License: GNU General Public License v2

  • Cost: Free

  • Version name: 1.26.0

  • Credit: The National Institutes of Health, the National Science Foundation.

  • Input: -

  • Output: -

  • Contact: Solaiappan Manimaran manimaran_1975@hotmail.com

  • Collection: -

  • Maturity: Stable

Publications

  • BatchQC: interactive software for evaluating sample and batch effects in genomic data.
  • Manimaran S, et al. BatchQC: interactive software for evaluating sample and batch effects in genomic data. BatchQC: interactive software for evaluating sample and batch effects in genomic data. 2016; 32:3836-3838. doi: 10.1093/bioinformatics/btw538
  • https://doi.org/10.1093/bioinformatics/btw538
  • PMID: 27540268
  • PMC: PMC5167063

Download and documentation


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