CAPE

CAPE is an R tool for a combined analysis of Pleiotropy and Epistasis to infer predictive networks between genotypes and phenotypes. The CAPE algorithm uses information on pleiotropic genes from different phenotypes to determine epistatic interaction models between alleles, and CAPE can analyze two-parent and multi-parent populations.

Topic

Genetics;Genotype and phenotype;Sequence analysis

Detail

  • Operation: Genetic variation analysis

  • Software interface: Library

  • Language: ;Combine complementary information across multiple related phenotypes to infer directed epistatic interactions between genetic markers. This analysis can be applied to a variety of engineered and natural populations.;Library;R

  • License: GNU General Public License v3

  • Cost: Free

  • Version name: 3.1.1

  • Credit: NIGMS, NCI, the Howard Hughes Medical Institute and the Hearst Endowment.

  • Input: -

  • Output: -

  • Contact: Anna Tyler Anna.Tyler@jax.org

  • Collection: -

  • Maturity: Mature

Publications

  • CAPE: an R package for combined analysis of pleiotropy and epistasis.
  • Tyler AL, Lu W, Hendrick JJ, Philip VM, Carter GW. CAPE: an R package for combined analysis of pleiotropy and epistasis. PLoS Comput Biol. 2013 Oct;9(10):e1003270. doi: 10.1371/journal.pcbi.1003270. Epub 2013 Oct 24. PMID: 24204223; PMCID: PMC3808451.
  • https://doi.org/10.1371/journal.pcbi.1003270
  • PMID: 24204223
  • PMC: PMC3808451

Download and documentation

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