CCFold

CCFold is a threading-based algorithm that produces accurate coiled-coil models from protein sequence data. It is specifically designed to handle hydrophobic repeat patterns in addition to the most common heptads. The algorithm is faster and more accurate than general-purpose computational folding, and when combined with Rosetta folding, it can generate representative dimer models for all IF protein classes.

Topic

Proteins;Protein sites, features and motifs;Protein folding, stability and design;Protein structure analysis

Detail

  • Operation: Protein secondary structure prediction (coils)

  • Software interface: Command-line user interface;Web user interface

  • Language: Python

  • License: The MIT License

  • Cost: Free

  • Version name: -

  • Credit: -

  • Input: -

  • Output: -

  • Contact: sergei.strelkov@kuleuven.be

  • Collection: -

  • Maturity: -

Publications

  • CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments
  • Guzenko D, Strelkov SV. CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments. Bioinformatics. 2018 Jan 15;34(2):215-222. doi: 10.1093/bioinformatics/btx551. PMID: 28968723.
  • https://doi.org/10.1093/bioinformatics/btx551
  • PMID: 28968723
  • PMC: -

Download and documentation

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