COCOA

"COCOA" is a computational framework to address the challenge of determining the biological significance of epigenetic variation among individuals. It introduces Coordinate Covariation Analysis, a tool capable of annotating epigenetic heterogeneity using the covariation of epigenetic signals across individuals and a database of region sets. While the primary focus is on DNA methylation data, COCOA is versatile enough to analyze any epigenetic signal with genomic coordinates. The tool demonstrates its utility through supervised and unsupervised analyses of DNA methylation, ATAC-seq, and multi-omic data.