CPDR

The 'CPDR' (Cancer-Personalized Drug Recommendation) is a user-friendly R package designed for personalized drug recommendation in the context of cancer treatment. It takes advantage of patient transcriptomic profiles and the Connectivity Map (CMAP) to make drug recommendations based on the individual disease signature. The tool offers three key features:
1. Identification of Disease Signature: CPDR identifies the individual disease signature by comparing the patient's transcriptomic profile to those of patient subgroups with similar profiles, which can assist in personalized drug selection.
2. Transcriptomic Profile Purification: In cases where the patient's profile may contain a high infiltration of non-cancerous cells, CPDR supports the purification of the transcriptomic profile for more accurate recommendations.
3. Customized Drug Recommendations: The tool provides personalized drug recommendations based on the patient's transcriptomic profile and the identified disease signature.
CPDR is a resource for improving the treatment response rate of cancer patients by tailoring drug recommendations to their unique transcriptomic profiles. It offers a practical workflow for clinicians and researchers involved in personalized cancer therapy.