CRIT

CRIT (CircRNA Regulator Identification Tool) is a pipeline to identify RNA-binding proteins (RBPs) involved in regulating circular RNAs (circRNAs) in cancer. Using genomics data and functional annotations, CRIT uncovered 73 novel regulators across thousands of samples.

Topic

Functional, regulatory and non-coding RNA;RNA immunoprecipitation;Oncology;RNA-Seq;Gene transcripts

Detail

  • Operation: RNA-binding protein prediction;RNA binding site prediction;Gene expression profiling

  • Software interface: Command-line interface

  • Language: R

  • License: Not stated

  • Cost: Free

  • Version name: -

  • Credit: The open fund of Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology.

  • Input: -

  • Output: -

  • Contact: Jianzhen Xu jzxu01@stu.edu.cn

  • Collection: -

  • Maturity: -

Publications

  • CRIT: Identifying RNA-binding protein regulator in circRNA life cycle via non-negative matrix factorization.
  • Shao M, et al. CRIT: Identifying RNA-binding protein regulator in circRNA life cycle via non-negative matrix factorization. CRIT: Identifying RNA-binding protein regulator in circRNA life cycle via non-negative matrix factorization. 2022; 30:398-406. doi: 10.1016/j.omtn.2022.10.015
  • https://doi.org/10.1016/J.OMTN.2022.10.015
  • PMID: 36420213
  • PMC: PMC9664520

Download and documentation

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