CSDeconv

CSDeconv is a software tool designed to determine the precise locations of transcription factor binding from ChIP-seq data. Unlike prior methods, CSDeconv uses a blind deconvolution approach that can accurately call closely-spaced binding sites. This unique approach sets CSDeconv apart from other computational methods in the field.

The Authors have applied the method to novel and existing ChIP-seq data to demonstrate the efficacy of CSDeconv. In the case of Mycobacterium tuberculosis, the Authors used the tool to analyze ChIP-seq data for DosR binding. The results showed that CSDeconv could accurately determine binding sites, even when separated by as few as 40 bp. Similarly, they used the tool to analyze existing ChIP-seq data for GABP in humans, successfully discriminating binding sites separated by 40 bp or less.