ConSeq
ConSeq is a web server that is used for identifying biologically important residues in protein sequences. It does this by analyzing the estimated evolutionary rates and the relative solvent accessibility predictions of each amino acid in the sequence.
The tool aims to identify residues that have potential structural or functional importance in maintaining the protein's fold. Additionally, ConSeq identifies residues that take part in ligand binding and protein-protein interactions. These residues are often evolutionarily conserved and are most likely to be solvent-accessible.
The tool is useful for researchers in the bioinformatics community who aim to identify biologically important residues in protein sequences. The identification of these residues can provide insights into the protein's function and structure, which can be useful in drug discovery and targeted therapy.
Topic
Protein folding, stability and design;Small molecules;Protein folds and structural domains;Structure prediction;Protein interactions
Detail
Operation: Sequence alignment analysis (conservation);Residue interaction prediction;Accessible surface calculation;Protein model validation;Protein fold recognition
Software interface: Web user interface
Language: Perl
License: Other
Cost: Free for only by Academic End Users solely for non-commercial research purposes.
Version name: 1.00
Credit: -
Input: -
Output: -
Contact: bioSequence@tauex.tau.ac.il
Collection: -
Maturity: Stable
Publications
- ConSeq: the identification of functionally and structurally important residues in protein sequences.
- Berezin C, et al. ConSeq: the identification of functionally and structurally important residues in protein sequences. ConSeq: the identification of functionally and structurally important residues in protein sequences. 2004; 20:1322-4. doi: 10.1093/bioinformatics/bth070
- https://doi.org/10.1093/bioinformatics/bth070
- PMID: 14871869
- PMC: -
Download and documentation
Source: https://consurf.tau.ac.il/STANDALONE/stand_alone_consurf-1.00.rar
Documentation: https://consurf.tau.ac.il/consurf_quick_help.php
Home page: http://conseq.bioinfo.tau.ac.il/
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