ConSeq

ConSeq is a web server that is used for identifying biologically important residues in protein sequences. It does this by analyzing the estimated evolutionary rates and the relative solvent accessibility predictions of each amino acid in the sequence.

The tool aims to identify residues that have potential structural or functional importance in maintaining the protein's fold. Additionally, ConSeq identifies residues that take part in ligand binding and protein-protein interactions. These residues are often evolutionarily conserved and are most likely to be solvent-accessible.

The tool is useful for researchers in the bioinformatics community who aim to identify biologically important residues in protein sequences. The identification of these residues can provide insights into the protein's function and structure, which can be useful in drug discovery and targeted therapy.

Topic

Protein folding, stability and design;Small molecules;Protein folds and structural domains;Structure prediction;Protein interactions

Detail

  • Operation: Sequence alignment analysis (conservation);Residue interaction prediction;Accessible surface calculation;Protein model validation;Protein fold recognition

  • Software interface: Web user interface

  • Language: Perl

  • License: Other

  • Cost: Free for only by Academic End Users solely for non-commercial research purposes.

  • Version name: 1.00

  • Credit: -

  • Input: -

  • Output: -

  • Contact: bioSequence@tauex.tau.ac.il

  • Collection: -

  • Maturity: Stable

Publications

  • ConSeq: the identification of functionally and structurally important residues in protein sequences.
  • Berezin C, et al. ConSeq: the identification of functionally and structurally important residues in protein sequences. ConSeq: the identification of functionally and structurally important residues in protein sequences. 2004; 20:1322-4. doi: 10.1093/bioinformatics/bth070
  • https://doi.org/10.1093/bioinformatics/bth070
  • PMID: 14871869
  • PMC: -

Download and documentation


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