DEEPsc

DeepSc is a software tool used for imputing spatial information onto single-cell RNA sequencing (scRNA-seq) data using a deep learning-based approach. It takes into account a spatial reference atlas and uses a system-adaptive model to map the scRNA-seq data to the reference atlas. The tool evaluates several metrics to assess its accuracy, precision, and robustness compared to other methods. Additionally, it provides a data-adaptive way to connect scRNA-seq datasets and spatial imaging datasets for analyzing cell fate decisions. The implementation of DeepSc includes a uniform API and is available as an open-source software.