DIANA-LNCBase

The LncRNADisease database is a valuable resource for the bioinformatics community that aims to understand the roles of long-non-coding RNAs (lncRNAs) in various diseases. In recent years, there has been increasing evidence that lncRNAs play critical roles in various biological processes, and their dysfunctions are associated with a wide range of diseases. Therefore, it becomes essential to identify lncRNAs that can be used as candidate biomarkers for disease diagnosis, treatment, and prognosis. The LncRNADisease database is a comprehensive collection of approximately 480 entries of experimentally supported lncRNA-disease associations, including 166 diseases. The database also includes 478 entries of lncRNA interacting partners at various molecular levels, such as protein, RNA, miRNA, and DNA. This information is crucial for understanding the molecular mechanisms underlying lncRNA involvement in diseases. The database provides annotated lncRNA-disease associations with genomic information, sequences, references, and species. The curated entries are normalized for disease name and the type of lncRNA dysfunction, and each entry is accompanied by a detailed description. This information facilitates easy access to relevant data and enables researchers to effectively utilize the database for their research projects. In addition to the experimentally supported lncRNA-disease associations, the database also includes a bioinformatic method to predict novel lncRNA-disease associations. The method was developed by integrating the predicted associated diseases of 1564 human lncRNAs into the database. This approach allows researchers to identify novel candidate lncRNA biomarkers for various diseases, which can aid in the development of novel diagnostic and therapeutic strategies.