DMRforPairs

DMRforPairs is a specialized software tool designed to analyze methylation data from Illumina Infinium HumanMethylation450 BeadChip arrays, focusing on comparing regional methylation status between unique, individual samples. This tool addresses a significant epigenetic gap by comparing methylation levels across genomic regions between two samples without needing larger sample groups. This capability is precious in studies where obtaining large sample sizes is impractical or impossible.

DMRforPairs operates by identifying probe-dense genomic regions and quantitatively assessing and testing the differences in methylation levels between the samples.

Topic

Epigenetics;Sequence sites, features and motifs;Microarray experiment

Detail

  • Operation: Methylation analysis;Sequence feature comparison

  • Software interface: Command-line user interface,Library

  • Language: R

  • License: GNU General Public License, version 2

  • Cost: Free

  • Version name: 1.38.0

  • Credit: ESPE Research Fellowship, Translational Grant, Erasmus MC.

  • Input: Nucleic acid features [Sequence feature annotation format]

  • Output: Sequence features [png] [TSV] [HTML] [PDF], Plot [png] [TSV] [HTML] [PDF]

  • Contact: Martin Rijlaarsdam m.a.rijlaarsdam@gmail.com

  • Collection: -

  • Maturity: Stable

Publications

  • DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles.
  • Rijlaarsdam MA, et al. DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles. DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles. 2014; 15:141. doi: 10.1186/1471-2105-15-141
  • https://doi.org/10.1186/1471-2105-15-141
  • PMID: 24884391
  • PMC: PMC4046028

Download and documentation

< Back to DB search