DeFuse

DeFuse is a tool for the identification of gene fusions in RNA-seq data. The deFuse algorithm examines all conflicting paired-end sequence alignments to find fusion boundaries.

Topic

Gene structure;RNA-seq;Gene transcripts;Oncology

Detail

  • Operation: Sequence motif discovery;Splicing model analysis;Gene expression comparison;RNA-Seq analysis

  • Software interface: Command-line user interface

  • Language: C++

  • License: Other

  • Cost: Free for non-commercial use

  • Version name: -

  • Credit: The British Columbia Cancer Foundation, the Vancouver General Hospital Foundation, Genome Canada, the Michael Smith Foundation for Health Research, the Canadian Breast Cancer Foundation, the Canadian Institutes of Health Research Bioinformatics Training Program.

  • Input: -

  • Output: -

  • Contact: Sohrab P. Shah sshah@bccrc.ca

  • Collection: -

  • Maturity: -

Publications

  • deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.
  • McPherson A, et al. deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. 2011; 7:e1001138. doi: 10.1371/journal.pcbi.1001138
  • https://doi.org/10.1371/journal.pcbi.1001138
  • PMID: 21625565
  • PMC: PMC3098195

Download and documentation

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