DeconRNASeq

DeconRNASeq is an R package for deconvolution of heterogeneous tissues based on mRNA-Seq data. The package employs a globally optimized non-negative decomposition algorithm through quadratic programming to estimate the mixing proportions of distinctive tissue types in next-generation sequencing data. The efficacy of DeconRNASeq was demonstrated using mRNA-Seq data mixed in silico at known concentrations and various benchmark data, with high correlation between predicted cell proportions and real fractions of tissues.