Diffany

Diffany is a software tool that allows the generation, visualization, and analysis of differential networks in response to changing environmental conditions or stimuli. It uses a novel ontology-driven framework that can process highly heterogeneous networks, accounting for both physical interactions and regulatory associations, symmetric and directed edges, edge weights, and negation. The tool is available as a free, open-source java library and Cytoscape plugin and promotes comparability between differential network studies. It was successfully applied in a plant abiotic stress study and experimentally confirmed a predicted regulator.

Topic

Molecular interactions, pathways and networks

Detail

  • Operation: Pathway or network analysis

  • Software interface: Command-line user interface;Graphical user interface

  • Language: Java

  • License: -

  • Cost: Free

  • Version name: 1.0.0

  • Credit: Ghent University (Multidisciplinary Research Partnership Bioinformatics: from nucleotides to networks), the Research Foundation Flanders (FWO), the Interuniversity Attraction Poles Program initiated by the Belgian Science Policy Office, by Ghent University (Bijzonder Onderzoeksfonds Methusalem project, Multidisciplinary Research Partnership Biotechnology for a Sustainable Economy project.

  • Input: -

  • Output: -

  • Contact: yves.vandepeer@psb.vib-ugent.be

  • Collection: -

  • Maturity: Emerging

Publications

  • Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks.
  • Van Landeghem S, et al. Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks. Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks. 2016; 17:18. doi: 10.1186/s12859-015-0863-y
  • https://doi.org/10.1186/s12859-015-0863-y
  • PMID: 26729218
  • PMC: PMC4700732

Download and documentation

< Back to DB search