EnrichedHeatmap

The "EnrichedHeatmap" R package emerges as a potent tool designed to meet the growing demands for analyzing the burgeoning volumes of high-throughput sequencing data. It specializes in generating enriched heatmaps, which effectively illustrate the enrichment of genomic signals across specified target regions. This visualization technique is particularly adept at uncovering enrichment patterns within high-dimensional genomic and epigenomic datasets, thereby facilitating a deeper understanding of complex biological mechanisms.

One of EnrichedHeatmap's key strengths is its advanced solutions for normalizing genomic signals within target regions, coupled with its capability to provide highly customizable visualizations. This ensures that users can tailor the heatmap outputs to meet the specific needs of their analysis, enhancing interpretability and insight. Moreover, EnrichedHeatmap supports the creation of parallel heatmaps and complex annotations with ease, enabling researchers to integrate and visualize intricate patterns and associations across and within complex datasets seamlessly.

The utility of EnrichedHeatmap is underscored by its application in visualizing the intricate relationships among DNA methylation, gene expression, and various histone modifications. Through such comprehensive visualizations, EnrichedHeatmap not only aids in understanding high-dimensional genomic and epigenomic data but also fosters the discovery of novel insights into the regulatory mechanisms underlying biological processes and diseases.

Topic

Data visualisation;Nucleic acid sites, features and motifs

Detail

  • Operation: Heat map generation

  • Software interface: Command-line user interface,Library

  • Language: R

  • License: GNU General Public License, version 2

  • Cost: Free

  • Version name: 1.32.0

  • Credit: The German Cancer Research Center-Heidelberg Center for Personalized Oncology, the BMBF-funded de.NBI HD-HuB network.

  • Input: Sequence range [Textual format], Nucleic acid features [Textual format], Gene expression data [Textual format]

  • Output: Heat map [Image format]

  • Contact: Zuguang Gu z.gu@dkfz.de

  • Collection: -

  • Maturity: Stable

Publications

  • EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations.
  • Gu Z, et al. EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations. EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations. 2018; 19:234. doi: 10.1186/s12864-018-4625-x
  • https://doi.org/10.1186/s12864-018-4625-x
  • PMID: 29618320
  • PMC: PMC5885322

Download and documentation


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