FORGE

FORGe (Favorable Omega-Representation Genome) is a software tool to enhance the reference genome by incorporating genetic variants and creating a graph genome with alternative sequences. This approach aims to improve read alignment accuracy and minimize allelic bias.

The tool addresses the challenges associated with adding variants to the reference genome, such as increased ambiguity and computational costs related to storing and querying the genome index. FORGe introduces methods to model and prioritize variants based on their impact on alignment accuracy and computational overhead.

By employing FORGe, users can achieve a balance between accuracy and computational efficiency, enabling them to make informed decisions when augmenting the reference genome with genetic variants.