FRASER

FRASER identifies alternative splicing and captures intron retention events, thereby increasing the number of detected aberrant events. It automatically accounts for latent confounders, enhancing sensitivity. FRASER employs a count distribution and multiple testing correction, substantially reducing the number of calls while maintaining sensitivity.

Topic

RNA splicing;RNA-Seq;Gene transcripts;Rare diseases;Functional, regulatory and non-coding RNA

Detail

  • Operation: Splice site prediction;Splicing model analysis;Genotyping;Visualisation

  • Software interface: Command-line user interface

  • Language: R,C++

  • License: The MIT License

  • Cost: Free

  • Version name: 1.14.0

  • Credit: Projekt DEAL.

  • Input: -

  • Output: -

  • Contact: Christian Mertes mertes@in.tum.de

  • Collection: -

  • Maturity: Stable

Publications

  • Detection of aberrant splicing events in RNA-seq data using FRASER.
  • Mertes C, Scheller IF, Yépez VA, Çelik MH, Liang Y, Kremer LS, Gusic M, Prokisch H, Gagneur J. Detection of aberrant splicing events in RNA-seq data using FRASER. Nat Commun. 2021 Jan 22;12(1):529. doi: 10.1038/s41467-020-20573-7. Erratum in: Nat Commun. 2022 Jun 16;13(1):3474. PMID: 33483494; PMCID: PMC7822922.
  • https://doi.org/10.1038/s41467-020-20573-7
  • PMID: 33483494
  • PMC: PMC7822922

Download and documentation

< Back to DB search