FuncPatch

FuncPatch is a web server that performs a fast approximate Bayesian inference of conserved functional patches in protein tertiary structures, which is an improvement over existing methods that ignore the spatial correlation of substitution rates in protein tertiary structures. It is shown that FuncPatch is a good approximation to the slower GP4Rate, and simulations suggest that it is potentially a useful tool complementary to Rate4Site. FuncPatch is orders of magnitude faster than GP4Rate and is supported by experimental evidence.

Topic

Molecular modelling;Protein structure analysis;Protein structural motifs and surfaces

Detail

  • Operation: Protein feature detection

  • Software interface: Web user interface

  • Language: -

  • License: -

  • Cost: Free

  • Version name: -

  • Credit: National Sciences and Engineering Research Council of Canada (NSERC) Discovery grant

  • Input: -

  • Output: -

  • Contact: -

  • Collection: -

  • Maturity: -

Publications

  • FuncPatch: a web server for the fast Bayesian inference of conserved functional patches in protein 3D structures.
  • Huang YF and Golding GB. FuncPatch: a web server for the fast Bayesian inference of conserved functional patches in protein 3D structures. FuncPatch: a web server for the fast Bayesian inference of conserved functional patches in protein 3D structures. 2015; 31:523-31. doi: 10.1093/bioinformatics/btu673
  • https://doi.org/10.1093/bioinformatics/btu673
  • PMID: 25322839
  • PMC: -

Download and documentation

    Currently not available or not maintained.

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