GAC
GAC is a software tool that provides a web-based suite for interactive visualization of clinical associations using high-dimensional data, such as gene expression, combined with clinical data. The tool is based on supervised principal component analysis (SuperPC), an approach that uses both high-dimensional data and clinical data to infer clinical associations.
The approach has been extended to address binary outcomes, in addition to continuous and time-to-event data, thereby increasing the use and flexibility of SuperPC. The tool also offers an interactive visualization for summarizing results based on a forest plot for binary and time-to-event data.
One of the primary advantages of GAC is that it provides a one-stop-shop for conducting statistical analysis to identify and visualize the association between a clinical outcome of interest and high-dimensional data types, such as genomic data.
Topic
Machine learning;Medicine
Detail
Operation: Principal component plotting;Statistical calculation
Software interface: Web application;Suite
Language: R
License: GNU General Public License v3
Cost: Free
Version name: -
Credit: Biostatistics and Bioinformatics Shared Resource of Winship Cancer Institute of Emory University, NIH/NCI.
Input: -
Output: -
Contact: manali.rupji@emory.edu
Collection: -
Maturity: -
Publications
- GAC: Gene Associations with Clinical, a web based application.
- Zhang X, Rupji M, Kowalski J. GAC: Gene Associations with Clinical, a web based application. F1000Res. 2017 Jul 3;6:1039. doi: 10.12688/f1000research.11840.4. PMID: 29263780; PMCID: PMC5658710.
- https://doi.org/10.12688/f1000research.11840.4
- PMID: 29263780
- PMC: PMC5658710.4
Download and documentation
Documentation: https://bbisr.shinyapps.winship.emory.edu/GAC/
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