GAC

GAC is a software tool that provides a web-based suite for interactive visualization of clinical associations using high-dimensional data, such as gene expression, combined with clinical data. The tool is based on supervised principal component analysis (SuperPC), an approach that uses both high-dimensional data and clinical data to infer clinical associations.

The approach has been extended to address binary outcomes, in addition to continuous and time-to-event data, thereby increasing the use and flexibility of SuperPC. The tool also offers an interactive visualization for summarizing results based on a forest plot for binary and time-to-event data.

One of the primary advantages of GAC is that it provides a one-stop-shop for conducting statistical analysis to identify and visualize the association between a clinical outcome of interest and high-dimensional data types, such as genomic data.

Topic

Machine learning;Medicine

Detail

  • Operation: Principal component plotting;Statistical calculation

  • Software interface: Web application;Suite

  • Language: R

  • License: GNU General Public License v3

  • Cost: Free

  • Version name: -

  • Credit: Biostatistics and Bioinformatics Shared Resource of Winship Cancer Institute of Emory University, NIH/NCI.

  • Input: -

  • Output: -

  • Contact: manali.rupji@emory.edu

  • Collection: -

  • Maturity: -

Publications

  • GAC: Gene Associations with Clinical, a web based application.
  • Zhang X, Rupji M, Kowalski J. GAC: Gene Associations with Clinical, a web based application. F1000Res. 2017 Jul 3;6:1039. doi: 10.12688/f1000research.11840.4. PMID: 29263780; PMCID: PMC5658710.
  • https://doi.org/10.12688/f1000research.11840.4
  • PMID: 29263780
  • PMC: PMC5658710.4

Download and documentation


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