GBAT

GBAT is a gene-based analytical pipeline designed to enhance the detection of transcriptional regulation signals, particularly focusing on the challenge of identifying high-quality distal associations, known as trans-eQTLs. Recognizing that disease-associated genetic variants often lie outside of exons and play significant roles in transcriptional regulation, the development of GBAT aims to address the difficulties encountered in trans-eQTL discovery. These challenges include a heavy burden of multiple testing and susceptibility to false-positive results, which have historically limited the identification of meaningful trans-gene regulatory signals.