HetEnc
HetEnc is a deep learning-based tool to integrate and analyze multi-platform gene expression data for single or multi-task classification problems in biological research. The tool consists of two main modules:
1. An unsupervised feature representation module that constructs three different encoding networks to represent the original gene expression data using high-level abstracted features.
2. A supervised neural network module with a six-layer fully connected feed-forward neural network, which is trained using the abstracted features for each targeted endpoint.
HetEnc's key advantage is its ability to handle multi-platform data during feature abstraction and model training while requiring only single-platform data for prediction. It reduces gene expression profiling costs for new samples and enables broader application of the trained model.
Topic
Machine learning;Molecular interactions, pathways and networks;Gene expression
Detail
Operation: Essential dynamics;Principal component visualisation;Expression analysis
Software interface: Command-line interface
Language: Python
License: Not stated
Cost: Free of charge
Version name: -
Credit: -
Input: -
Output: -
Contact: Leihong Wu Leihong.wu@fda.hhs.gov
Collection: -
Maturity: -
Publications
- HetEnc: a deep learning predictive model for multi-type biological dataset.
- Wu L, et al. HetEnc: a deep learning predictive model for multi-type biological dataset. HetEnc: a deep learning predictive model for multi-type biological dataset. 2019; 20:638. doi: 10.1186/s12864-019-5997-2
- https://doi.org/10.1186/S12864-019-5997-2
- PMID: 31395005
- PMC: PMC6686264
Download and documentation
Documentation: https://github.com/seldas/HetEnc_Code/blob/master/README.md
Home page: https://github.com/seldas/HetEnc_Code
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