HetEnc

HetEnc is a deep learning-based tool to integrate and analyze multi-platform gene expression data for single or multi-task classification problems in biological research. The tool consists of two main modules:

1. An unsupervised feature representation module that constructs three different encoding networks to represent the original gene expression data using high-level abstracted features.

2. A supervised neural network module with a six-layer fully connected feed-forward neural network, which is trained using the abstracted features for each targeted endpoint.

HetEnc's key advantage is its ability to handle multi-platform data during feature abstraction and model training while requiring only single-platform data for prediction. It reduces gene expression profiling costs for new samples and enables broader application of the trained model.

Topic

Machine learning;Molecular interactions, pathways and networks;Gene expression

Detail

  • Operation: Essential dynamics;Principal component visualisation;Expression analysis

  • Software interface: Command-line interface

  • Language: Python

  • License: Not stated

  • Cost: Free of charge

  • Version name: -

  • Credit: -

  • Input: -

  • Output: -

  • Contact: Leihong Wu Leihong.wu@fda.hhs.gov

  • Collection: -

  • Maturity: -

Publications

  • HetEnc: a deep learning predictive model for multi-type biological dataset.
  • Wu L, et al. HetEnc: a deep learning predictive model for multi-type biological dataset. HetEnc: a deep learning predictive model for multi-type biological dataset. 2019; 20:638. doi: 10.1186/s12864-019-5997-2
  • https://doi.org/10.1186/S12864-019-5997-2
  • PMID: 31395005
  • PMC: PMC6686264

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