I-TASSER

The I-TASSER server is an online tool for predicting protein structure and related functions. It is a widely used resource in the scientific community for various biological and biomedical investigations. The server applies advanced techniques, such as multiple threading alignment approaches, to recognize structural templates from the Protein Data Bank (PDB). Iterative fragment assembly simulations construct the produced full-length structure models. The server also derives functional insights from these models by matching them with known proteins in the function databases.

To address the feedback from the user community and enhance the accuracy of the predictions, recent developments have been made to the I-TASSER server. These improvements include introducing new methods for atomic-level structure refinement, local structure quality estimation, and biological function annotations. These new developments are crucial in improving the quality of the I-TASSER server for high-resolution structure and function prediction.