ISOWN

ISOWN is a software tool to discriminate somatic single nucleotide mutations from germline polymorphism in next-generation sequencing datasets. The ISOWN algorithm uses a machine learning approach and does not require control samples of normal tissue.

Topic

Genomics;Oncology;DNA polymorphism

Detail

  • Operation: Genetic variation analysis

  • Software interface: Command-line user interface

  • Language: Java, Perl

  • License: Apache License v 2.0

  • Cost: Free

  • Version name: -

  • Credit: The Ontario Institute for Cancer Research, the Ontario Ministry of Research, Innovation and Science.

  • Input: VCF

  • Output: -

  • Contact: Irina Kalatskaya ikalats@gmail.com

  • Collection: -

  • Maturity: -

Publications

  • ISOWN: accurate somatic mutation identification in the absence of normal tissue controls.
  • Kalatskaya I, Trinh QM, Spears M, McPherson JD, Bartlett JMS, Stein L. ISOWN: accurate somatic mutation identification in the absence of normal tissue controls. Genome Med. 2017 Jun 29;9(1):59. doi: 10.1186/s13073-017-0446-9. PMID: 28659176; PMCID: PMC5490163.
  • https://doi.org/10.1186/s13073-017-0446-9
  • PMID: 28659176
  • PMC: PMC5490163

Download and documentation

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