IgGeneUsage

IgGeneUsage is an R-package for analyzing differential immunoglobulin (Ig) gene usage in immune repertoires. The tool utilizes Bayesian inference with hierarchical models to study complex gene usage data from high-throughput sequencing experiments. By employing probabilistic quantification of differential Ig gene usage, IgGeneUsage addresses limitations associated with current practices of null hypothesis significance testing.

Topic

Statistics and probability;Genetics;Bioinformatics

Detail

  • Operation: Differential gene expression analysis;Quantification;Peptide immunogenicity prediction

  • Software interface: Plug-in

  • Language: R

  • License: -

  • Cost: Free

  • Version name: 1.16.0

  • Credit: Deutsche Forschungsgemeinschaft.

  • Input: -

  • Output: -

  • Contact: Simo Kitanovski simo.kitanovski@uni-due.de

  • Collection: -

  • Maturity: Stable

Publications

  • IgGeneUsage: differential gene usage in immune repertoires.
  • Kitanovski S and Hoffmann D. IgGeneUsage: differential gene usage in immune repertoires. IgGeneUsage: differential gene usage in immune repertoires. 2020; 36:3590-3591. doi: 10.1093/bioinformatics/btaa174
  • https://doi.org/10.1093/BIOINFORMATICS/BTAA174
  • PMID: 32163125
  • PMC: -

Download and documentation

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