IgRepertoireConstructor

The IgRepertoireConstructor is an open-source software tool designed for analyzing antibody repertoires, which presents challenging computational difficulties due to the extensive diversification of antibodies. The tool performs error-correction of immunosequencing reads and utilizes mass spectra for validating the constructed antibody repertoires. The tool is available in C++ and Python and runs on all Unix-compatible platforms.

Topic

Immunology;Immunoproteins, genes and antigens;Gene and protein families;Infectious disease;Sequencing

Detail

  • Operation: Sequencing error detection

  • Software interface: Command-line user interface

  • Language: C++;Perl;Python;C

  • License: Other

  • Cost: Free

  • Version name: Y-tools 3.1.1

  • Credit: Russian Science Foundation, National Institute of Health.

  • Input: -

  • Output: -

  • Contact: Yana Safonova safonova.yana@gmail.com

  • Collection: -

  • Maturity: Stable

Publications

  • IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis.
  • Safonova Y, et al. IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis. 2015; 31:i53-61. doi: 10.1093/bioinformatics/btv238
  • https://doi.org/10.1093/bioinformatics/btv238
  • PMID: 26072509
  • PMC: PMC4542777

Download and documentation

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