KDDN

The KDDN is a Java Cytoscape app that constructs differential dependency networks using an integrated molecular network learning method, which optimally integrates prior biological knowledge with measured data. KDDN can simultaneously construct common and differential networks, assign model parameters and significant rewiring p-values, and provide user-friendly graphical results. KDDN is computationally efficient and provides users with parallel computing capability using multi-core machines.

Topic

Data integration and warehousing;Gene expression;Microarray experiment;Systems biology;Molecular interactions, pathways and networks

Detail

  • Operation: Pathway or network analysis

  • Software interface: Graphical user interface

  • Language: Java

  • License: -

  • Cost: Free

  • Version name: 1.1.0

  • Credit: National Institutes of Health (NIH).

  • Input: -

  • Output: -

  • Contact: Yue Wang yuewang@vt.edu

  • Collection: -

  • Maturity: Stable

Publications

  • KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring.
  • Tian Y, et al. KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring. KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring. 2015; 31:287-9. doi: 10.1093/bioinformatics/btu632
  • https://doi.org/10.1093/bioinformatics/btu632
  • PMID: 25273109
  • PMC: PMC4287948

Download and documentation

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