KnowSeq

The 'KnowSeq' R package is a comprehensive and modular software tool for automating and integrating various bioinformatic tools. It facilitates complex gene expression analyses, offering a unified environment to identify gene signatures associated with specific diseases. 'KnowSeq' handles raw files from different sources and transcriptomic technologies, employing advanced algorithms for tasks such as gene selection in multiclass problems. The tool incorporates an intelligent classification system, allowing users to choose from well-known classification and feature selection methods. Additionally, it automatically generates detailed HTML reports of the analysis. Experimental cases involving bi-class breast cancer and multiclass lung cancer demonstrate the efficacy of KnowSeq in achieving high classification rates and extracting relevant biological knowledge.

Topic

RNA-Seq;Transcriptomics;Workflows;Molecular interactions, pathways and networks;Ontology and terminology

Detail

  • Operation: Data retrieval;Differential gene expression profiling;Pathway visualisation

  • Software interface: Library

  • Language: R

  • License: GNU General Public License, version 2

  • Cost: Free

  • Version name: 1.16.0

  • Credit: -

  • Input: -

  • Output: -

  • Contact: Daniel Castillo-Secilla cased@ugr.es

  • Collection: -

  • Maturity: Stable

Publications

  • KnowSeq R-Bioc package: The automatic smart gene expression tool for retrieving relevant biological knowledge.
  • Castillo-Secilla D, et al. KnowSeq R-Bioc package: The automatic smart gene expression tool for retrieving relevant biological knowledge. KnowSeq R-Bioc package: The automatic smart gene expression tool for retrieving relevant biological knowledge. 2021; 133:104387. doi: 10.1016/j.compbiomed.2021.104387
  • https://doi.org/10.1016/J.COMPBIOMED.2021.104387
  • PMID: 33872966
  • PMC: -

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