LOT

LOT is a tool for performing linkage analysis of ordinal traits for pedigree data. It uses a latent-variable proportional-odds logistic model to relate inheritance patterns to the distribution of the ordinal trait and implements the likelihood-ratio test for testing evidence of linkage. This tool is particularly useful for analyzing complex diseases and human conditions that are rated on ordinal scales, such as behavioral disorders.

Topic

Genetics;Linkage

Detail

  • Operation: Linkage analysis;Analysis

  • Software interface: Graphical user interface

  • Language: Java

  • License: Other

  • Cost: Free

  • Version name: 1.2

  • Credit: The National Institutes on Drug Abuse.

  • Input: Locus data file and pedigree file

  • Output: -

  • Contact: Heping Zhang heping.zhang@yale.edu

  • Collection: -

  • Maturity: -

Publications

  • Linkage analysis of ordinal traits for pedigree data.
  • Feng R, et al. Linkage analysis of ordinal traits for pedigree data. Linkage analysis of ordinal traits for pedigree data. 2004; 101:16739-44. doi: 10.1073/pnas.0404623101
  • https://doi.org/10.1073/pnas.0404623101
  • PMID: 15548606
  • PMC: -
  • LOT: a tool for linkage analysis of ordinal traits for pedigree data.
  • Zhang M, et al. LOT: a tool for linkage analysis of ordinal traits for pedigree data. LOT: a tool for linkage analysis of ordinal traits for pedigree data. 2008; 24:1737-9. doi: 10.1093/bioinformatics/btn258
  • https://doi.org/10.1093/bioinformatics/btn258
  • PMID: 18535081
  • PMC: PMC2566542

Download and documentation

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