LipiDex

LipiDex is an advanced software tool for lipid identification in liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments. Unlike traditional proteomics software, the field of discovery lipidomics has yet to develop comparably mature informatics tools. This is where LipiDex comes in as a game-changer. It unifies and automates all stages of lipid identification, reducing hands-on processing time from hours to minutes, even for the most expansive datasets.

LipiDex utilizes flexible in silico fragmentation templates and lipid-optimized MS/MS spectral matching routines to confidently identify and track hundreds of lipid species and unknown compounds from various sample matrices. It also accurately quantifies co-isolation and co-elution of isobaric lipids, generating identifications that match the structural resolution afforded by the LC-MS/MS experiment. This means that researchers can obtain more accurate experiment results and save time by automating the identification process.

One of the unique features of LipiDex is the use of spectral and chromatographic peak purity algorithms. These algorithms accurately quantify the co-elution and co-isolation of isobaric lipids, which is essential for generating identifications that match the structural resolution afforded by the LC-MS/MS experiment. During final data filtering, ionization artifacts are removed to significantly reduce dataset redundancy.

LipiDex interfaces with several LC-MS/MS software packages, enabling robust lipid identification to be readily incorporated into pre-existing data workflows. Researchers can easily integrate LipiDex into their existing processes and workflows without hassles or disruptions.