MARRVEL

MARRVEL (model organism aggregated resources for rare variant exploration) is a web-based tool that integrates publicly available human and model organism genetic resources for functional studies of rare human gene variants in model organisms. MARRVEL extracts data from six human databases OMIM, ExAC, ClinVar, Geno2MP, DGV, DECIPHER, and from seven model organism databases SGD, PomBase, WormBase, FlyBase, ZFIN, MGI, and RGD. The MARRVEL site also proves APIs for programmatic data retrieval.

Topic

Genetic variation;Data acquisition;Genetics

Detail

  • Operation: Database search

  • Software interface: Database portal

  • Language: -

  • License: Database portal

  • Cost: Free

  • Version name: Beta 2.0

  • Credit: NINDS; the Model Organisms Screening Center of the UDN and NIH/ORIP, The Robert and Janice McNair Foundation McNair, Baylor College of Medicine Medical Scientist Training Program, NSF, CPRIT, Huffington Foundation, Belfer Foundation, T T Chao Family Foundation, NIH NIGMS, Dana Farber/Harvard Cancer Center, the Pediatric Neurology Basic Neuroscience Research Track residency training program at Baylor College of Medicine, the Texas Children’s Hospital (NRI Fellowship) and Alzheimer’s Association, the Simons Foundation.

  • Input: -

  • Output: -

  • Contact: zhandonl@bcm.edu

  • Collection: -

  • Maturity: Stable

Publications

  • Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity.
  • Wang J, Mao D, Fazal F, Kim SY, Yamamoto S, Bellen H, Liu Z. Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity. Curr Protoc Bioinformatics. 2019 Sep;67(1):e85.
  • https://doi.org/10.1002/cpbi.85
  • PMID: 31524990
  • PMC: PMC6750039
  • MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.
  • Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Comjean A, Mohr SE; UDN, Perrimon N, Liu Z, Bellen HJ. MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. Am J Hum Genet. 2017 Jun 1;100(6):843-853.
  • https://doi.org/10.1016/j.ajhg.2017.04.010
  • PMID: 28502612
  • PMC: PMC5670038
  • Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information.
  • Wang J, Liu Z, Bellen HJ, Yamamoto S. Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information. J Vis Exp. 2019 Aug 15;(150):10.3791/59542.
  • https://doi.org/10.3791/59542
  • PMID: 31475990
  • PMC: -

Download and documentation

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