MEGA

MEGA (Molecular Evolutionary Genetics Analysis) is a software tool package for analyzing and visualizing molecular evolution. The MEGA package includes a large variety of analysis methods, such as editing of aligned sequence data, construction of time trees, divergence estimation, computation of confidence intervals to calibrate parameters for node-dating tip-dating, and Bayesian method to estimate evolutionary probabilities and more.

Topic

Phylogenetics;Phylogeny;Population genetics;Sequence analysis;Genetics

Detail

  • Operation: DNA substitution modelling;Phylogenetic tree generation (from molecular sequences);Phylogenetic tree generation (maximum likelihood and Bayesian methods);Phylogenetic tree generation (parsimony methods);Genetic variation analysis

  • Software interface: Web user interface

  • Language: -

  • License: Proprietary

  • Cost: Free

  • Version name: 11.x

  • Credit: National Institutes of Health, National Science Foundation, Japan Society for the Promotion of Science (JSPS).

  • Input: -

  • Output: -

  • Contact: Sudhir Kumar s.kumar@temple.edu

  • Collection: -

  • Maturity: Mature

Publications

  • MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment
  • Kumar S, Tamura K, Nei M. MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform. 2004 Jun;5(2):150-63. doi: 10.1093/bib/5.2.150. PMID: 15260895.
  • https://doi.org/10.1093/bib/5.2.150
  • PMID: 15260895
  • PMC: -
  • MEGA2: molecular evolutionary genetics analysis software.
  • Kumar S, Tamura K, Jakobsen IB, Nei M. MEGA2: molecular evolutionary genetics analysis software. Bioinformatics. 2001 Dec;17(12):1244-5. doi: 10.1093/bioinformatics/17.12.1244. PMID: 11751241.
  • https://doi.org/10.1093/bioinformatics/17.12.1244
  • PMID: 11751241
  • PMC: -
  • MEGA-CC: computing core of molecular evolutionary genetics analysis program for automated and iterative data analysis
  • Kumar S, Stecher G, Peterson D, Tamura K. MEGA-CC: computing core of molecular evolutionary genetics analysis program for automated and iterative data analysis. Bioinformatics. 2012 Oct 15;28(20):2685-6. doi: 10.1093/bioinformatics/bts507. Epub 2012 Aug 24. PMID: 22923298; PMCID: PMC3467750.
  • https://doi.org/10.1093/bioinformatics/bts507
  • PMID: 22923298
  • PMC: PMC3467750
  • MEGA11: Molecular Evolutionary Genetics Analysis Version 11
  • Tamura K, Stecher G, Kumar S. MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Mol Biol Evol. 2021 Jun 25;38(7):3022-3027. doi: 10.1093/molbev/msab120. PMID: 33892491; PMCID: PMC8233496.
  • https://doi.org/10.1093/molbev/msab120
  • PMID: 33892491
  • PMC: PMC8233496
  • MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
  • Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007 Aug;24(8):1596-9. doi: 10.1093/molbev/msm092. Epub 2007 May 7. PMID: 17488738.
  • https://doi.org/10.1093/molbev/msm092
  • PMID: 17488738
  • PMC: -
  • MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
  • Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011 Oct;28(10):2731-9. doi: 10.1093/molbev/msr121. Epub 2011 May 4. PMID: 21546353; PMCID: PMC3203626.
  • https://doi.org/10.1093/molbev/msr121
  • PMID: 21546353
  • PMC: PMC3203626
  • MEGA6: Molecular Evolutionary Genetics Analysis version 6.0
  • Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013 Dec;30(12):2725-9. doi: 10.1093/molbev/mst197. Epub 2013 Oct 16. PMID: 24132122; PMCID: PMC3840312.
  • https://doi.org/10.1093/molbev/mst197
  • PMID: 24132122
  • PMC: PMC3840312
  • MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets
  • Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 2016 Jul;33(7):1870-4. doi: 10.1093/molbev/msw054. Epub 2016 Mar 22. PMID: 27004904; PMCID: PMC8210823.
  • https://doi.org/10.1093/molbev/msw054
  • PMID: 27004904
  • PMC: PMC8210823
  • MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms
  • Kumar S, Stecher G, Li M, Knyaz C, Tamura K. MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Mol Biol Evol. 2018 Jun 1;35(6):1547-1549. doi: 10.1093/molbev/msy096. PMID: 29722887; PMCID: PMC5967553.
  • https://doi.org/10.1093/molbev/msy096
  • PMID: 29722887
  • PMC: PMC5967553
  • Molecular Evolutionary Genetics Analysis (MEGA) for macOS
  • Stecher G, Tamura K, Kumar S. Molecular Evolutionary Genetics Analysis (MEGA) for macOS. Mol Biol Evol. 2020 Apr 1;37(4):1237-1239. doi: 10.1093/molbev/msz312. PMID: 31904846; PMCID: PMC7086165.
  • https://doi.org/10.1093/molbev/msz312
  • PMID: 31904846
  • PMC: PMC7086165
  • MEGA biocentric software for sequence and phylogenetic analysis: a review
  • Sohpal VK, Dey A, Singh A. MEGA biocentric software for sequence and phylogenetic analysis: a review. Int J Bioinform Res Appl. 2010;6(3):230-40. doi: 10.1504/IJBRA.2010.034072. PMID: 20615832.
  • https://doi.org/10.1504/IJBRA.2010.034072
  • PMID: 20615832
  • PMC: -

Download and documentation

< Back to DB search