MOGEN

MOGEN is a software tool designed to reconstruct 3D models of genomes from both intra- and inter-chromosomal Hi-C contact data. The software was validated on synthetic datasets of a polymer worm-like chain model and a yeast genome and then applied to generate an ensemble of 3D structural models of the genome of human B-cells from a Hi-C dataset. MOGEN is capable of handling noisy and inconsistent inter-chromosomal contact data and is a useful tool for converting chromosomal contact data into 3D genome models to provide a better view into the spatial organization of genomes.

Topic

Molecular modelling;Structural genomics;Immunology

Detail

  • Operation: Structure analysis

  • Software interface: Command-line user interface

  • Language: Java

  • License: GNU General Public License v3.0

  • Cost: Free

  • Version name: v1.0

  • Credit: National Science Foundation CAREER award

  • Input: -

  • Output: -

  • Contact: chengji@missouri.edu

  • Collection: -

  • Maturity: -

Publications

  • MOGEN: a tool for reconstructing 3D models of genomes from chromosomal conformation capturing data.
  • Trieu T and Cheng J. MOGEN: a tool for reconstructing 3D models of genomes from chromosomal conformation capturing data. MOGEN: a tool for reconstructing 3D models of genomes from chromosomal conformation capturing data. 2016; 32:1286-92. doi: 10.1093/bioinformatics/btv754
  • https://doi.org/10.1093/bioinformatics/btv754
  • PMID: 26722115
  • PMC: -

Download and documentation

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