Mango

Mango is a complete ChIA-PET data analysis pipeline that corrects for major sources of bias including differential peak enrichment and genomic proximity, and provides statistical confidence estimates for interactions. It performs all the required steps for processing ChIA-PET datasets and exhibits much better agreement with high-resolution Hi-C data compared to other existing software packages. Mango has been applied to multiple available ChIA-PET datasets and has independently rediscovered known trends in chromatin loops.

Topic

Data architecture, analysis and design;Statistics and probability;Structural genomics

Detail

  • Operation: Statistical calculation;Analysis

  • Software interface: Command-line user interface

  • Language: R;C++

  • License: GNU General Public License, version 2

  • Cost: Free

  • Version name: -

  • Credit: National Institutes of Health (NIH), the Damon Runyon Cancer Research Foundation.

  • Input: -

  • Output: All significant interactions, tested interactions

  • Contact: dphansti@email.unc.edu

  • Collection: -

  • Maturity: -

Publications

Download and documentation

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