MaxLink

MaxLink is a guilt-by-association network search algorithm that identifies and ranks genes that are tightly linked to a user-supplied list of query genes. This tool can be used to predict potential disease genes from an initial set of genes with known association to a disease. The algorithm has been updated to use a more statistically sound method for selection of candidate genes and made faster by re-implementation in C++.

Topic

Molecular interactions, pathways and networks;Systems biology;Oncology

Detail

  • Operation: Pathway or network prediction

  • Software interface: Web user interface

  • Language: C++;Perl

  • License: -

  • Cost: Free

  • Version name: 1.0.0

  • Credit: Premier Research Group, Merck AB.

  • Input: -

  • Output: -

  • Contact: dimitri.guala@scilifelab.se

  • Collection: -

  • Maturity: -

Publications

  • MaxLink: network-based prioritization of genes tightly linked to a disease seed set.
  • Guala D, et al. MaxLink: network-based prioritization of genes tightly linked to a disease seed set. MaxLink: network-based prioritization of genes tightly linked to a disease seed set. 2014; 30:2689-90. doi: 10.1093/bioinformatics/btu344
  • https://doi.org/10.1093/bioinformatics/btu344
  • PMID: 24849579
  • PMC: -

Download and documentation

< Back to DB search