MetTailor

MetTailor is a software package for preprocessing untargeted metabolomics data, which involves accurate peak alignment and reliable intensity normalization. The package features two novel data preprocessing steps, including a dynamic block summarization method for correcting misalignments and a flexible intensity normalization procedure that adjusts normalizing factors against the temporal variations in total ion chromatogram. MetTailor was evaluated using a curated metabolomics dataset and a large-scale dataset featuring over 100 sera samples in a primary Dengue infection study, demonstrating its effectiveness in correcting misaligned peaks and removing visible local variations in TIC.

Topic

Metabolomics;Proteomics experiment;Molecular interactions, pathways and networks

Detail

  • Operation: Spectral analysis;Analysis

  • Software interface: Command-line user interface

  • Language: R

  • License: -

  • Cost: Free

  • Version name: 2.0

  • Credit: -

  • Input: -

  • Output: -

  • Contact: hyung_won_choi@nuhs.edu.sg

  • Collection: -

  • Maturity: -

Publications

  • MetTailor: dynamic block summary and intensity normalization for robust analysis of mass spectrometry data in metabolomics.
  • Chen G, et al. MetTailor: dynamic block summary and intensity normalization for robust analysis of mass spectrometry data in metabolomics. MetTailor: dynamic block summary and intensity normalization for robust analysis of mass spectrometry data in metabolomics. 2015; 31:3645-52. doi: 10.1093/bioinformatics/btv434
  • https://doi.org/10.1093/bioinformatics/btv434
  • PMID: 26220962
  • PMC: -

Download and documentation

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