MetaBridge

MetaBridge is a web-based resource to analyze metabolomics data and interactively build a protein-protein interaction network. The MetaBridge algorithm uses data from the MetaCyc metabolic pathway and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases to map metabolite compounds to interacting upstream or downstream enzymes in enzymatic reaction pathways.

Topic

Small molecules;Protein interactions;Molecular interactions, pathways and networks

Detail

  • Operation: Protein interaction analysis

  • Software interface: Web user interface

  • Language: R

  • License: GNU General Public License v3

  • Cost: Free

  • Version name: 1.1

  • Credit: Canadian Institutes for Health Research, The University of British Columbia ‘Four Year Doctoral Fellowship’, ‘Canada Research Chair in Health and Genomics’, and ‘UBC Killam Professorship’.

  • Input: list of metabolite IDs

  • Output: csv

  • Contact: Robert E W Hancock bob@hancocklab.com

  • Collection: -

  • Maturity: Mature

Publications

  • MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping
  • Blimkie T, Lee AH, Hancock REW. MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping. Curr Protoc Bioinformatics. 2020 Jun;70(1):e98. doi: 10.1002/cpbi.98. PMID: 32199034; PMCID: PMC7299206.
  • https://doi.org/10.1002/cpbi.98
  • PMID: 32199034
  • PMC: PMC7299206
  • MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites.
  • Hinshaw SJ, Lee AHY, Gill EE, Hancock REW. MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites. Bioinformatics. 2018 Sep 15;34(18):3225-3227. doi: 10.1093/bioinformatics/bty331. PMID: 29688253.
  • https://doi.org/10.1093/bioinformatics/bty331
  • PMID: 29688253
  • PMC: -

Download and documentation

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