MethCoresProfiler

MethCoresProfiler is a software tool to tackle the complexities of analyzing DNA methylation, a crucial and stable epigenetic modification. Unlike traditional DNA methylation analysis methods, which focus on single-nucleotide resolution and average methylation levels, MethCoresProfiler offers a novel approach for identifying and tracing stable epialleles within complex DNA populations.

Key Features and Functionality

• Extraction of Methylated Phased CpGs: Enables the extraction of combinations of methylated phased CpGs, uncovering stable epialleles in complex DNA populations.
• Identification of Epiallele Families: Identifies and traces the families of epialleles, highlighting patterns of methylation shared across all components.
• Analysis of Stable Methylated Cores: Focuses on the stable methylated cores, characterized by high informational content and low stochasticity.
• Evolution of Epialleles: Tracks the evolution of epialleles as they acquire or lose new methyl sites, offering insights into the dynamics of DNA methylation.
• Validation with Synthetic and Real Data: The tool's reliability and utility have been validated through its application to both synthetic and real datasets.