MiSTIC

MISTIC (mutual information server to infer coevolution) is a web-based software tool that enables the graphical representation and analysis of the information contained within a multiple sequence alignment (MSA) for protein families. The tool provides a complete analysis of mutual information (MI) networks in protein families and outputs a graphical visualization of several information-related quantities using a circos representation.

MISTIC provides an integrated view of the MSA regarding the mutual information between residue pairs, sequence conservation, and the residue cumulative and proximity mutual information scores. The server also offers an interactive interface to explore and characterize the mutual information network, and several tools are available for selecting subsets of nodes from the network for visualization. The node coloring can be set to match different attributes, such as conservation, cumulative MI, proximity MI, and secondary structure.

One of the unique features of MISTIC is its ability to provide a comprehensive, compact, and visually rich view of the information contained within an MSA, making it an essential tool for bioinformatics research. The use of circos representation of MI networks and the visualization of the cumulative MI and proximity MI concepts is novel, making it an ideal tool for researchers who want to explore and visualize the relationships between residues in a protein family.

MISTIC provides a zip file containing all the results, which can be downloaded, making it easy to share with other researchers or collaborators.

Topic

Transcriptomics;Sequence analysis;Oncology

Detail

  • Operation: Sequence analysis

  • Software interface: Command-line user interface

  • Language: C++;Python

  • License: GNU General Public License v3

  • Cost: Free

  • Version name: -

  • Credit: Genome Quebec, Terry Fox Foundation, Canada Research Chair in the Molecular Genetics of Stem Cells, Cancer Research Network of the Fonds de Recherche du Québec-Santé, Australian Government National Health and Medical Research Council, Canadian Cancer Society Research Institute, Canadian Imperial Bank of Commerce breast cancer research chair at Université de Montréal.

  • Input: -

  • Output: -

  • Contact: sylvie.mader@umontreal.ca

  • Collection: -

  • Maturity: -

Publications

  • MISTIC: Mutual information server to infer coevolution.
  • Simonetti FL, et al. MISTIC: Mutual information server to infer coevolution. MISTIC: Mutual information server to infer coevolution. 2013; 41:W8-14. doi: 10.1093/nar/gkt427
  • https://doi.org/10.1093/nar/gkt427
  • PMID: 23716641
  • PMC: PMC3692073
  • MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.
  • Lemieux S, et al. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. 2017; 45:e122. doi: 10.1093/nar/gkx338
  • https://doi.org/10.1093/nar/gkx338
  • PMID: 28472340
  • PMC: PMC5570030

Download and documentation

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